Protodioscin from herbal plant tribulus terrestris L improves the male sexual functions, probably via DHEA
A. Adimoelja and P. Ganeshan Adaikan
Airlangga University, Indonesia and National University of Singapore in 6th Biennial Asian-Pacific
in Meeting on Impotence in Kuala Lumpur, Malaysia (1997)
Int. J. Impotence Research v9, supp 1 (1997)

SUMMARY

An interesting correlation of dehydroepiandrosterone-sulphate (DHEA-S) level with the incident of low sex drive and higher occurrence of impotence was discovered in studies with patients diagnosed with diabetes mellitus. To test further the relationship between DHEA-S and erectile dysfunction (ED), we conducted a clinical trial of 30 non-diabetic men with ED, 30 non-diabetic men without ED and 15 diabetic men with ED. These men are given extract of Tribulus terrestris (Libilov) at 3 x 250 mg / day for 3 weeks. The DHEA-S levels, as well as other blood and liver parameters were evaluated.

We found a significant increase of DHEA-S levels in diabetic and non-diabetic subjects after treatment, and a significant increase in the frequency of successful intercourse by 60% in both the diabetic and non-diabetic groups with or without ED.

Treatment of sexual dysfunction in diabetes mellitus subjects using orally administered protodioscin and injection of vasoactive compounds
A. Adimoelja
Academic Hospital Dr. Soetomo, Airlangga University, Surabaya, Indonesia
in Seminar of Erectile Dysfunction of Diabetes in Bandung, Indonesia (1997)

SUMMARY

Diabetes mellitus is a systemic metabolic disease which results in the destruction or weakening of many tissues and cell types. Here we conduct a preliminary clinical study to determine the level of dehydroepiandrosterone-sulphate (DHEA-S) in 15 diabetic males and 15 healthy controls. This study shows that the DHEA-S levels in healthy people are significantly higher than that found in diabetic subjects. A further study conducted with 30 male subjects with diabetes shows that those also suffering from erectile dysfunction (ED) have even lower DHEA-S levels than those without the dysfunction.

Treatment of diabetic subjects with protodioscin in form of tablets of Tribulus terrestris L extract (Libilov, 250 mg at 3 x 1 tablet daily for ten days) results in the increase of DHEA-S levels of these subjects, with the most gain experienced by those who also suffer from ED.

Moreover, in this study we notice a significant increase (> 60%) in the frequency of successful sexual intercourse, as well as increased libido or sex drive in the diabetic male subjects. In this clinical study, we find no unwanted side-effects of administration of Libilov as examined by laboratory blood tests, as well as kidney and liver function tests.

Effect of protodioscin (Tribulus terrestris) on the well-being and sexual response of men with diabetes mellitus
K.M. Arsyad
Medical Biology Division of Andrology, University of Sriwijaya, Indonesia (1997)

SUMMARY

We conducted this trial to study the effect of Tribulus terrestris (protodioscin) supplement on the sense of well-being and sexual response of men suffering from diabetes mellitus. 30 men between the ages of 40 to 55 years were divided into two 15-men groups. The experimental and control groups were given Tribulus terrestris extract (Libilov tablets, 250mg) and placebo pills 3 times per day for 30 days, respectively. Both groups were not statistically different in age, body weight and fasting sugar levels.

Our result showed that the Tribulus supplement is able to improve the sense of well being and sexual response of diabetic subjects. We found improvement in sex drive, erection, ejaculation and orgasm in the treated group and no improvement in these parameters in the control group.