Studies on Infertility, Virility & Ejaculate Quality
A. Adimoelja, L. Setiawan, and T. Djojotananjo
Academic Hospital Dr. Soetomo, Airlangga University, Surabaya, Indonesia
in First International Conference of Medical Plants for Reproductive
Medicine in Taipei, Taiwan (1995)
Tribulus terrestris L (TTL) extract is a natural remedy that has
been successfully tested clinically for its use in the treatment
of idiopathic oligoasthenoteratozoospermia (OTA). Here, we conducted
a double blind study of 45 infertile, married men with OTA. 36 men
were treated with 500 mg purified TTL (Libilov) 3 times daily for
3 months. Composing the controlled group, 9 men were given placebo
(sugar pills) for the same period of time. Spouses of 8 of the men
in the treated group successfully achieved pregnancies after treatment
of their husbands, whereas no pregnancies occurred in the spouses
of the men in the control group. An improvement in the sperm morphology,
including that observed under conventional phase contrast microscopy
as well as improvements in acrosome morphology and reaction, seemed
to account for the increased fertility after treatment. In addition,
TTL was also shown to increase the level of dehydroepiandrosterone
(DHEA) and might also contribute to the activation of cell membrane
receptors and the production of weak androgens. These, in turn,
might additionally improve fertility by increasing the level of
Medical Biology Division of Andrology, University of Sriwijaya,
Medika 22 (8): 614-618 (1996)
This study was conducted to assess the effectiveness of a certain
dosage and period of administration of Libilov (protodioscin) on
sperm quality and quantity in men with moderate idiopathic oligozoospermia.
This study also evaluated protodioscin's effect on libido, erection,
ejaculation and orgasm. Lastly, We also determined the length of
time that the beneficial effects of the treatment lasted after administration
of the preparation was stopped.
Our result showed that oral Libilov treatment with the dose of
3 x 2 tablets per day for 60 days could:
- increase sperm quantity and quality in men diagnosed with moderate
- restore and enhance libido, erection, ejaculation, and orgasm
of sexual intercourse, as compared to before the treatment. This
result was obtained in more than 80% of the treated patients.
Airlangga University, Surabaya, Indonesia (1996)
Here we investigated the effects of Tribulus terrestris L. on sperm
morphology and acrosome reaction in subjects with oligoasthenoteratozoospermia.
A double-blind placebo-controlled trial was performed with 30 primary
and secondary infertile men. Half received oral Tribulus (Libilov,
500mg dose) three times per day for 60 days, and the rest were given
sugar pills. The ejaculate volume, sperm concentration, morphology,
acrosome reactions, and other parameters were evaluated before and
A significant increase in the percentage of slow or sluggish progressive
motile sperm in the treated group was observed when compared to
the control group. The percentage of the sperm with normal acrosome
reaction was also increased, whereas the percentage of immotile
sperm decreased significantly.
The frequency of sexual intercourse was also increased significantly
in the Tribulus group. No side effect was observed. We concluded
that Tribulus terrestris L., given at 500mg three times a day for
60 days proved to be effective in restoring some of the sperm functions,
such as motility and acrosome reactions.
N. Moeloek, A. Adimoelja, T. Tanojo, and W. Pangkahila
Proceedings of the VIth National Congress and IIIrd International
Symposium on New Perspectives of Andrology on Human Reproduction
National Congress of Indonesian Association of Andrologs. Scientific
Meeting VI in Manado (1994)
Tribulus terrestris L. is a natural, non-hormonal herbal preparation.
This trial focuses on determining the effect of this preparation
on the fertility of men with oligozoospermia.
A three-centered study in Indonesia (the cities of Jakarta, Surabaya,
and Denpasar) include 45 subjects. Thirty six of these men compose
the experimental group, and are administered Tribulus terrestris
L. (Libilov), whereas 9 are given placebo (control group).
The study includes analyses of three phases:
- Before treatment - During treatment (9 weeks) - After treatment
(3 weeks after treatment)